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Content & Annotation Sets

GenomOncology is committed to maintaining an extensive knowledge of all aspects related to precision oncology, encompassing FDA-approved therapies, clinical trials, and diverse annotation sets. By leveraging our in-house curation team and partnerships with esteemed content institutions, GenomOncology has developed a robust knowledge base within our Precision Oncology Platform. This knowledge base serves as the foundation for our comprehensive clinical informatics solutions for cancer.

Discover more about our clinical data curation services and the curated content and annotation sets available within GenomOncology's knowledge base.

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Data Curation Services


Data Curation

GenomOncology's dedicated in-house curation team extracts data-driven insights from unstructured data. Our team of precision medicine experts specializes in clinical data abstraction and curation, enhancing access to concise structured data for scientific research, analysis, and institution-specific data strategies.

With a specific focus on clinical trials, FDA-approved and guideline-based therapies, private protocols, pathology reports, NGS reports, and institution-specific clinical protocols, GenomOncology's in-house curation team leverages our advanced NLP and quality assurance solution, igniteIQ, to streamline data extraction and analysis. By combining automated processes with manual review, we ensure efficient and accurate extraction of clinical data, facilitating the utilization of institution-specific or valuable data to enhance opportunities and outcomes.

Quality Control

To ensure the accuracy of extraction and curation, GenomOncology employs both automated and manual validation methods. Our in-house curation team utilizes streamlined technology and established rules and specifications to guarantee output accuracy. Additionally, we employ a quality control tool that presents a side-by-side view of imaged documents and discrete data elements, reducing extraction errors and ensuring the integrity of the overall extraction process.

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Curated Content

All biomarker-based clinical trials and therapies are curated and accessible within our precision oncology solutions due to our in-house curation team, and partnerships with leading content institutions.

Data Set Annotations

Our team validates numerous data sets, such as ClinVar, COSMIC, and gnomAD, on a quarterly basis, ensuring the latest data sets are available within the precision oncology solutions.

Institution-Specific Content

Proprietary content and data specific to an institution can be added to GenomOncology’s precision oncology solution set, enabling the incorporation of licensed content or history assertions.

Curated Content

Through our in-house curation and partnerships with leading content institutions, we provide the following curated content within our precision oncology solutions.

Ontologies
  • Alterations

  • Drugs

  • Diseases

  • Anatomic Sites

  • References

Assertions
  • Clinical Trials

  • Therapies

  • Prognosis

  • Diagnosis

  • Protein Effect

  • Narrative Content

GenomOncology databases now include 689 EU and UK Assertions.

There are 462 European therapeutic assertions-

  • 193 EMA approvals

  • 269 ESMO guidelines

There are 441 UK therapeutic assertions-

  • 191 MHRA approvals

  • 128 NICE guidelines

  • 122 SMC guidelines

Leading Content Institution Partners

Annotations

GenomOncology's solution sets include the following validated data sets, which are updated quarterly.

  • HGVS nomenclature

  • Mutation Type

  • ClinVar

  • COSMIC

  • dbSNP

  • gnomAD

  • ExAC

  • 1000 Genomes

  • Oncogene/tumor suppressor

  • Cancerhotspots.org

  • PolyPhen

  • SIFT

  • dbNSFP (38 prediction/conservation algorithms)

  • HGMD

  • OMIM

  • HPO

  • mitomap

  • gnomAD gene

  • REVEL

  • UniProt

  • ACMG Secondary Findings